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GCRA Publications
REFERENCES TO PAPERS DEALING WITH SIGNIFICANCE OF GCRA DRUGS
AS THERAPIES FOR CANCER AND INFLAMMATION
1. Shailubhai, K., Yu, H. H., Karunanandaa, K., Wang, J. Y., Eber, S. L.,
Wang, Y., Joo, N. S., Kim, H. D., Miedema, B. W., Abbas, Z., Boddupalli,
S. B., Mark G. Currie., and Forte, L. R. Uroguanylin treatment suppresses
polyps formation in APCmin/+ mouse and induces apoptosis in human colon
adenocarcinoma cells by a cGMP dependent mechanism. Cancer Res. (2000),
60: 5151-5157.
Animal data supporting colon cancer as target for GCRA drug. (download
pdf)
2. Shailubhai, K., Forte, L. R., Yu, H. H., Karunanandaa,
K., Wang, J. Y., Eber, S. L., Wang, Y., Joo, N.S., Kim, H. D.,
Miedema, B.W., Abbas,
Z., Boddupalli, S. S., and Currie, M. G. (1999) Oral administration
of uroguanylin inhibits polyps formation in APCmin/+ mouse by
a novel mechanism involving
induction of apoptosis in epithelial cells of the intestinal mucosa.
In Proceedings of the AACR · NCI · EORTC International Conference.
(http://www.aacr.org/newdrugs/latebreaking/0734.html).
3. Forte LR. Guanylin regulatory peptides: structures, biological activities
mediated by cyclic GMP and pathobiology. Regul. Pept. (1999) 81:25-39.
Review article describing recent advances on therapeutic applications.
4. Shailubhai, K. Therapeutic Applications
of Guanylate Cyclase-C Agonists. (2002) Current Opinion in
Drug Discovery and Development. 5:261-268
Review article describing recent advances suggesting GCRA drug applications
in cancer, inflammation and asthma.
5. Pitari GM, Di Guglielmo MD, Park J, Schulz S, Waldman SA. Guanylyl cyclase
C agonists regulate progression through the cell cycle of human colon carcinoma
cells. Proc. Natl. Acad. Sci. (USA) ( 2001) 98: 7846-7851.
6. Pitari GM, Zingman LV, Hodgson DM, Alekseev AE, Kazerounian S, Bienengraeber
M, Hajnoczky G, Terzic A, Waldman SA.(2003)
Bacterial enterotoxins are associated with resistance to colon
cancer. Proc Natl Acad Sci U S A. 100: 2695-2699. Epub 2003 Feb 19.
Paper supporting colon cancer as a target for GCRA drugs.
6. Liu L, Li H, Underwood T, Lloyd M, David M, Sperl G, Pamukcu R, Thompson
WJ. Cyclic GMP-dependent protein kinase activation and induction by exisulind
and CP461 in colon tumor cells. J. Pharmacol. Exp. Ther. (2001) 299: 583-592.
Paper supporting GCRA drug and phospohodiesterase inhibitors as drugs for
colon cancer.
7. Gene Expression profiles in normal and cancer cells. Zhang L, Zhou W,
Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B, Kinzler KW.
Science (1997) 276:1268-1272.
Gene expression profiling data in normal vs. colon cancer tissues. (paper
attached)
8. Obayashi H, Yamaichi QUI. Both inhalant and intravenous uroguanylin
inhibit leukotriene C4-induced airway changes. Peptides (2000) 21:1467-1472.
This and following two papers describe animal data supporting use of GCRA
drug for treating asthma.
9. Rodger IW. Role of leukotrienes and leukotriene receptor antagonist
in asthma: new advances. J. Investig. Allergol. Clin. Immunol. (1997) 7:
279.
10. Ohbayashi H, Yamaki K, Suzuki R, Takagi K. Effects of uroguanylin and
guanylin against antigen-induced bronchoconstriction and airway microvascular
leakage in sensitized guinea-pigs. Life Sci. (1998) 62:1833-1844.
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